Silver Protein Review:
Reduction in HIV Viral Load in Mild Silver
Protein Case Studies
by Kimberly Pryor
A recent article appearing in the
Clinical Practice of Alternative Medicine lends further merit to
the use of silver as an anti-viral agent. The article titled
?Reduction of Viral Load in AIDS Patients with Intravenous Mild
Silver Protein--Three Case Reports? is an intriguing glimpse
into the potential applications of an important, but often
overlooked metal. In the article, study authors Dean, Mitchell,
Whizar-Lugo, and South, explore silvers history in the
pre-antibiotic era--and report their impressive results on the
intravenous use of mild silver protein in three case studies.
Antibiotic Predecessor
The authors chose mild silver protein (MSP) as the means to
treat three HIV-positive patients because silver has been used
since the 19th century as an anti-microbial agent, with a wide
range of bactericidal, fungicidal and virucidal properties. As
the authors report in their paper, silver, unlike its heavy
metal cousins, is surprisingly non-toxic to humans and animals,
and has a long history of successful medical and public health
use dating back 6000 years. It has been used to speed wound
healing, treat
infections, purify water and preserve beverages.(1)
When silver use was in its heyday, from 1900 until 1940, various
forms were used to treat hundreds of ailments, including burn
infections, pneumonia, tuberculosis, pleurisy, gonorrhea,
syphilis wounds, leg ulcers, pustular eczema, impetigo and
boils. It has been used in acute meningitis and epidemic
cerebrospinal meningitis, Mediterranean fever, erysipelas,
cystitis, typhus, typhoid fever, tonsillitis, dacryocystitis,
corneal ulcers, conjunctivitis, blepharitis, and various forms
of septicemia, including puerperal fever, peritonitis and
post-abortion septicemia.
In their study, Dean et. al. explore the timeline of silvers use
as an effective anti-microbial agent. At the beginning of the
modern antibiotic era, which began in the 1940s, silver as an
antibacterial compound fell into disuse. Today, however,
antibiotics are not known as the panacea they once were, due to
the emergence of antibiotic-resistant microorganisms.
Antibiotics also can destroy beneficial intestinal bacteria,
disrupting the gut flora necessary for proper health.
Broad-Spectrum Antimicrobial
One of the reasons Dean, et al., chose silver for their
experimental studies is because silver is unique among
antimicrobial agents in its broad spectrum of action. It has
killed some 650 different disease organisms, including
gram-positive and gram-negative bacteria, spore-forming
bacteria, fungus/ yeasts including several Aspergillus varieties
and 50 different clinical isolates of Candida albicans, viruses,
protozoal parasites, 95% of 72 strains of herpes virus, and the
malaria-causing Plasmodium berghei. It is widely reported in the
medical literature that silver, often at surprisingly low
concentrations, routinely kills bacteria known to be
antibiotic-resistant.
In order to use one of the most effective types of silver
available, the authors used mild silver protein (MSP). Combining
silver with protein enhances the minerals action. The protein
acts as a stabilizer and solubilizer for the silver particles,
preventing them from combining with each other to form
ever-larger particles that would settle out of suspension.
The authors of the Clinical Practice of Alternative Medicine
study theorized that if silver played such an important
anti-viral, anti-bacterial historical role, intravenous
administration should inhibit the HIV virus thought to be
responsible for AIDS.
New Silver Study
The reason the study is worth spotlighting is not because of its
scope but rather because of its startling outcome. In fact, the
study had a rather surprising origin in that it wasnt a
researcher who initiated the investigation, but rather a
Louisiana-based businessman named Bill McFarland. In 1994, a
physician friend introduced McFarland to MSP. He began to use it
for minor viral infections, and recommended it to friends for
oral and topical use for a variety of clinical conditions.
Having witnessed mild silver proteins beneficial effects,
McFarland wondered whether it could play a part in the treatment
of serious, difficult-to-treat infectious diseases. If MSP
proved to be as effective intravenously as it was orally, then
MSP could be a significant player in the fight against certain
conditions.
In 1997, McFarland recruited three subjects with HIV to
participate in clinical trials with MSP overseen by physicians.
The initial protocol involved progressively increasing amounts
and concentrations administered orally for 30-60 days, followed
by a series of intravenous infusions in concentrations ranging
from 40 PPM to 1,500 PPM. Subjects started out with oral MSP 40
PPM and advanced to 400 PPM, taking several teaspoons daily in
divided doses for approximately one month prior to intravenous
administration. Oral MSP 400 PPM was continued throughout the
test period.
In the first phase of this small trial, a physician administered
120 ml of MSP in concentrations of 40, 400, and 1,500 PPM
respectively to each of two subjects [AP and RC], over 2 to 3
hours, in a carrier solution to which dimethyl sulfoxide (DMSO)
was added.
HIV Viral Load Reduction
The first subject, AP, a white male born in 1967, was diagnosed
with HIV in February 1993. In April 1995, AP began to experience
nausea, vomiting, diarrhea, and shingles. Roughly a year and a
half later, he sought regular medical treatment for anxiety,
diarrhea, and weight loss. Physicians had prescribed
intermittent courses of antibiotics for diarrhea, acyclovir for
shingles, and AZT. However, AP seldom completed a course of any
of these medications. At the time he entered the experimental
trial with MSP in October 1997, AP was medication-free and was
unable to walk without assistance due to fatigue and weakness.
His viral load was over 750,000 RNA copies/ml--the maximum
detectable limit of the instrument.
The physicians gave AP his first IV infusion on December 3, 1997
(Fig. 1). What the researchers discovered at this point should
be enough to turn the heads of many physicians. Thirty-five days
after beginning MSP treatment, APs viral load was 39,000 RNA
copies/ml. ?One month later,? the authors report, ?with no
additional infusions, the viral load was down to 400 RNA
copies/ml (the lowest detectable limit of the instrument).? AP
continued to improve clinically, left New Orleans in February
1998, and was lost to follow-up.
The second subject, RC, was a Puerto Rican male, born in 1950,
who had tested positive for HIV in 1987. RCs medical history
also included Hepatitis A and B. He had been a waiter most of
his adult life, and also worked as a carpenter with his father
on weekends, renovating houses. The researchers were unable to
obtain viral load or T-cell count data for RC, but, when first
diagnosed, he had been under the impression he had only two
years to live. It wasnt until the summer of 1997, however, that
he noticed decreased energy and increased need for sleep. He was
so debilitated he could no longer work. He volunteered for the
experimental MSP treatment program in November 1997.
RC received five IV infusions on the same dates and dosages as
AP (Fig. 2). He received a sixth infusion of MSP 400 PPM on
February 27 in the US and continued on oral MSP 400 PPM until
June of 1998, when he discontinued participation in the program.
RC noted a dramatic restoration of his energy levels and
returned to his former occupation as a waiter, where he usually
worked 12-hour days. Because of his restored energy levels, RC
no longer felt a need to participate in the study. Today, RC is
employed, and continues to decline further treatment, as he does
not feel ill.
The third subject, GH, was a white male, born in 1948, who had
been HIV+ since 1985. He began taking oral MSP 400 PPM 1 tsp
three times daily on April 4 1998. His HIV-1 RNA (viral load)
test on June 9, 1998 was 13,752 RNA copies/ml. On June 10, 1998
he was given one infusion of MSP 400 PPM. He continued oral MSP
through the end of July,1998. On July 20, a second HIV-1 RNA
test was performed: his viral load had dropped dramatically to
2,215 RNA copies/ml.
In each of the subjects, the benefits were substantial. The only
adverse effect of the 400 PPM or less infusions was a Herxheimer-like
reaction. On December 7, after his only infusion of 1500 PPM MSP,
AP suffered a particularly severe Herxheimer (also known as a
?die-off?) reaction characterized by weakness and severe
myalgias that continued for days, instead of the hours-long
reactions seen in the other subjects. Nevertheless, by January
4, AP demanded he be given another infusion. Herxheimer
reactions sometimes occur when the body is exposed to a
beneficial, detoxifying agent. As the substance causes harmful
microbes (viruses, bacteria, fungi) to die, the body can
experience a temporary toxic onslaught. When these harmful
substances are completely expelled, the Herxheimer reaction
subsides.
AP also experienced severe pancytopenia (reduction in blood cell
production) after the administration of MSP 1,500 PPM. The
researchers learned that 1,500 PPM was clearly a toxic dose. All
adverse effects reversed themselves rapidly, however, and MSP
proved to be otherwise safe. However, it was clear that
extremely high doses of MSP, administered intravenously, were
probably toxic, as demonstrated by a dramatic drop in healthy
blood markers, such as decreased hemoglobin levels in APs blood
following the 1,500 PPM infusion.
The authors admitted the data presented were fragmentary.
However, these cases illustrate that MSP can indeed have an
impact on one of the most difficult-to-treat conditions there is
-- AIDS. I believe that the medical and scientific community
should take the hint and pick up where this small experimental
study concluded.
As the study authors state, ??we believe the reductions in viral
load in these subjects are so dramatic that they deserve
publication. The well-documented results are certainly no
coincidence, and cannot be ignored.?
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References:
1. Dean W, Mitchell M, Whizar Lugo V, South J. Reduction of
Viral Load in AIDS Patients with Intravenous Mild Silver
Protein--Three Case Reports. Clinical Practice of Alternative
Medicine. Spring, 2001.
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