Acetyl-L-Carnitine (ALC) and Alpha-Lipoic Acid Improve Energy and Memory
Noted University of California biochemist and cancer researcher, Bruce N. Ames, has formed a new company, Juvenon, to conduct new trials to support the findings of three scientific articles published in the Feb 19 2002 issue of the Proceedings of the National Academy of Sciences. In the published papers Ames and fellow researchers report that a combination of two dietary supplements — alpha-lipoic acid (ALA), and acetyl-L-carnitine (ALC)—can dramatically increase energy levels and improve memory in aging laboratory rats.
Ames and his fellow researchers report that the two compounds work by quenching free radicals that tend to build up inside mitochondria—the power plants of cells in the body. Deterioration of mitochondria is an important cause of aging and the decline of memory and the body's energy, Ames and colleagues contend.
With the two supplements together, these old rats got up and did the Macarena, Ames stated. The brain looks better, they are full of energy—everything we looked at looks more like a young animal.
Along with the reports Ames announced that he and his colleagues were forming Juvenon to conduct a series of carefully controlled human trials to confirm what they already believe are remarkable results from the combination of Lipoic Acid and ALC.
I didn't really want to found a company, and I have no commercial interest in it myself, Ames said in an interview yesterday, but we want to do really solid science in this venture because there is so much snake oil out there.
Already Juvenon scientists have reported gathering anecdotal evidence from more than 50 healthy older human volunteers taking the combination of the two antioxidant supplements. The volunteers have reported a wide variety of positive effects, the company says, including: Increased energy, elevated mood, steady emotional state, improved sleep, enhanced cognitive function, weight loss or improved weight control, decreased age pigment (lipofuscin) and lower blood pressure.
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